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New Synthesis of Uric Acid and 1,7-Dimethyluric Acid 1

โœ Scribed by Bills, C. Wayne; Gebura, Stanley E.; Meek, John S.; Sweeting, Orville J.


Book ID
120514544
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
381 KB
Volume
27
Category
Article
ISSN
0022-3263

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A synthetic procedure for l13-di(trideuteromethyl)uric acid is described. Deuterium labeling of the N-1 and N-3 positions w a s achieved by methylation of 4-amino-5carbethoxyuracil with di( trideuteromethy1)-sulfate followed by cyclization of the dimethylated intermediate by heating. The synthesis r