The condensation of phosphorus ylids with t-butyl N(diphenylmethylene) oxamate gives 2-aza 1,3-dienes ; subsequent reduction with sodium cyanoborohydride provides protected a-aminoacids.
New synthesis of protected α-dehydro α-aminoacids from substituted oxamic acid
✍ Scribed by J.P. Bazureau; M. Le Corre
- Book ID
- 104217521
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 101 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
the condensation of a phosphorus ylid with t-butoxalyl iminoether gives 3-carbobutoxy 2-aza 1,3-dienes ; subsequent reaction with hydriodic acid provides protected a-dehydro a-amino acids (1).
Syntheses of a-amino acids from nucleophilic amino acid synthons A are well
📜 SIMILAR VOLUMES
The two enantiomers of the title dehydroamino acids (DHAAs) have been synthesized through respective Wadsworth-Emmons condensations of a suitable phosphonate with enantiomeric cyclobutyl aldehydes. These compounds, in turn, were prepared by selective manipulation of the functional groups starting fr
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