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New synthesis of leukotriene B3 methyl ester from bis(trimethylsilyl) unsaturated derivatives

✍ Scribed by Francesco Babudri; Vito Fiandanese; Omar Hassan; Angela Punzi; Francesco Naso

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
516 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

A new synthesis of leukotriene B3 methyl ester is reported, starting from bis(trimethylsilyl) unsaturated derivatives as building blocks for the triene moiety of the leukotriene. The two stereogenic centers have been generated by enantioselective chemical reduction of two acetylenic ketones with both R-or S-Alpine Borane R. The three conjugated double bonds system of the leukotriene has been assembled by Miyaura-Suzuki cross-coupling reaction.

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