New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid
✍ Scribed by Alberto Milanese; Elena Gorincioi; Mehdi Rajabi; Giulio Vistoli; Enzo Santaniello
- Book ID
- 113492503
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 500 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0045-2068
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## Abstract 6‐[3‐(1‐Adamantyl)‐4‐methoxyphenyl]‐2‐naphthoic acid (1), a promising new compound for the treatment of disorders of keratinization, has been synthesized in [^14^C]‐labelled form from barium [^14^C]‐carbonate via labelled benzene. Benzene‐[U‐^14^C] was converted to 4‐bromo‐methoxybenzen
Vilsmeier-Haack type reaction on isoxazolin-5-ones is presented. Recently described is zin-6-ones. 2 The synthetic We report here on the the preparation of a number of E-amino-' and 2-phenyl-6H-1,3-oxapotential of such a class of compounds is well documented.3 syntheses by a Vilsmeier-Haack type rea