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New synthesis of 2-substituted 2-oxazolines: transition-metal-catalyzed cross-coupling of Grignards with 2-(methylthio)-4,4-dimethyl-2-oxazoline

โœ Scribed by Pridgen, Lendon N.; Killmer, Lewis B.


Book ID
127298660
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
391 KB
Volume
46
Category
Article
ISSN
0022-3263

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Synthesis of 2,4- and 2,5-Disubstituted
โœ Carla M. Counceller; Chad C. Eichman; Nicolas Proust; James P. Stambuli ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 180 KB ๐Ÿ‘ 1 views

## Abstract The rapid synthesis of 2,4โ€ and 2,5โ€disubstituted oxazoles __via__ metalโ€catalyzed crossโ€coupling reactions is reported. The 4โ€ or 5โ€position of the corresponding 4โ€ or 5โ€halogenated 2โ€butylthiooxazoles was successfully functionalized __via__ Suzukiโ€“Miyaura, Sonogashira and Stille cross