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New Syntheses of the Bis-Guanylhydrazone and Bis-Thiosemicarbazone of Methylglyoxal

✍ Scribed by N. A. Keiko; T. N. Mamashvili


Book ID
106491334
Publisher
Springer
Year
2005
Tongue
English
Weight
62 KB
Volume
39
Category
Article
ISSN
0091-150X

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## Abstract The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal‐__bis__[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine. We have looked at the relative MGBG toxicity of two differen