New Syntheses of Pyrylium Salts

✍ Scribed by Dr. Richard Schmidt

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 112 KB
• Volume: 3
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.196403871

✦ Synopsis

The following observations confirm this course of reaction: 1 . Reduced pyridine nucleotide (DPNH) is formed only in presence of cis-p,y-enoyl hydrase, racemase and HOADH. D-( -)-$-Hydroxylauroyl-CoA (2) is dehydrogenated to (4) only in presence of racemase and HOADH.

2. After incubation of 35 pmoles of [5-14C]-cis-3-dodecenoyl-

CoA ( I ) with cis-$,y-enoyl hydrase and racemase, 3.0 mg of methyl rat.$-hydroxylaurate (m.p. 27 "C) were isolated by saponification, esterification and gas-chromatographic separation. The optical rotation of methyl D+)-or L-(+)-$hydroxylaurate ([a]ko = 19.5'; c = 1 in CHCl3)did not change in the blank under the conditions of isolation. Through these reactions the unsaturated fatty acids are connected with the metabolic cycle of the saturated fatty acids [4], so that our knowledge of the $-oxidation of all the fatty acids occurring in the animal kingdom is thereby complete.