New syntheses of diaza-crown ethers using boc protecting groups
β Scribed by Krzysztof E. Krakowiak; Jerald S. Bradshaw
- Book ID
- 112131380
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1995
- Tongue
- English
- Weight
- 174 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-152X
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π SIMILAR VOLUMES
We have previously described the conditions by which peptide synthesis by the solid-phase fragment condensation approach can be carried out using crown ethers as non-covalent protection for the N alpha-amino group. Here we demonstrate that the procedure can be extended to large, partially protected
Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied. The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF. The formation of 3-benzyltyrosine from e-benzyl tyrosine in
## Abstract A new microwaveβenhanced method for rapid demethylation of methyl phenyl ethers using neat methanesulfonic acid (CH~3~SO~3~H) is presented. Using a monomodal microwave cavity, cleavage of anisole (**1**), used as model compound, to phenol (**2**) was achieved with high conversions (ca 8