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New strategy for convergent synthesis of trans-fused polyether frameworks based on palladium-catalyzed suzuki cross-coupling reaction

✍ Scribed by Makoto Sasaki; Haruhiko Fuwa; Masayuki Inoue; Kazuo Tachibana


Book ID
104260208
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
227 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


A new strategy for convergent synthesis of trans-fused polyethers based on palladium(0)catalyzed Suzuki cross-coupling reaction of alkylboranes with cyclic enol triflates has been developed. The present method allows to construct polyether frameworks rapidly and efficiently.


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The synthesis of 3-amino-6-(hetero)arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine (1a) and 3-amino-6-iodopyridazine (1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved method