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New stereoselective synthesis of the peptidic aminopeptidase inhibitors bestatin, phebestin and probestin

โœ Scribed by Giuliana Righi; Claudia D'Achille; Giovanna Pescatore; Carlo Bonini


Book ID
104254364
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
117 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Peptidic aminopeptidase inhibitors, bestatin, phebestin and probestin have been prepared by stereo-and regiocontrolled reactions from a common a,b-epoxy ester precursor.


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Aminopeptidase inhibitors, phebestin, probestin and bestatin have been prepared by stereospecific reduction of ot-keto amide precursors using zinc borohydride.