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New stereoselective synthesis of 20S and 20R steroidal side chains. Remarkable stereoselectivity differences between saturated and .alpha.,.beta.-unsaturated steroidal esters

โœ Scribed by Ibuka, Toshiro; Taga, Tooru; Shingu, Tetsuro; Saito, Masako; Nishii, Shinji; Yamamoto, Yoshinori


Book ID
121685227
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
807 KB
Volume
53
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


Regio and stereochemically controlled ri
โœ J.R. Schauder; A. Krief ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 255 KB

This epoxide was obtained stereoselectively (> 95% ) on reaction of corresponding C-2O,C-22 olefin with osmium tetroxide (1.2 eq., 10ยฐ,1hr,85X yield) followed by basic cyclisation of the resulting C-2O,C-22 diol via its C-22 monomesylate (74% overall yield).