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New Sphingolipids and Other Constituents of Pancovia laurentii

✍ Scribed by Ferdinand Tantangmo; Bruno Ndjakou Lenta; Silvère Ngouela; Louis Marie Kamdem; Bernard Weniger; Etienne Tsamo; Annelise Lobstein; Catherine Vonthron-Sénécheau

Book ID
102256564
Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
183 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Phytochemical investigation of the bark and leaves of Pancovia laurentii (Sapindaceae) resulted in the isolation of a new ceramide and a new cerebroside, named pancoviamide (1), and pancovioside (2) respectively, together with six known compounds: uracil, (R)‐N‐[(1__S__,2__S__,3__R__)‐2,3‐dihydroxy‐1‐(hydroxymethyl)heptadec‐5‐en‐1‐yl]‐2‐hydroxytetracosanamide, stigmasta‐7,22‐dien‐3‐ol, β‐stitosterol, β‐sitosterol 3‐O‐β‐D‐glucopyranoside, and 2,3‐dihydroxypropyl pentadecanoate. The structures of 1 and 2 were determined by means of spectroscopic methods. Compounds 1 and 2 were tested in vitro for their antiprotozoal properties against several protozoa and for their cytotoxicity.

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