A new simple method for the synthesis of
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Shlomo Cohen; Gadi Rothenberg; Yoel Sasson
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Article
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1998
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Elsevier Science
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French
⚖ 125 KB
A clean and efficient intramolecular cyclization of 5-halovaleronitrile to cyclobutyl cyanide was achieved using NaOH and phase-transfer catalysts in a solid-liquid system at 70 °C.