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New, simple and versatile synthesis of 4,6-disubstituted pyridazin-3(2H)-ones

✍ Scribed by Albrecht, Anna; Koszuk, Jacek; Kobuciński, Michał; Janecki, Tomasz

Book ID: 119948764
Publisher: Royal Society of Chemistry
Year: 2008
Tongue: English
Weight: 117 KB
Volume: 6
Category: Article
ISSN: 1477-0520
DOI: 10.1039/B718734C

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## Abstract magnified image Different analogues of TMC120 derived from pyridazin‐3(2__H__)‐one rings were synthesized by coupling of 3,6‐dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.