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Synthesis of some novel 2,6-disubstituted pyridazin-3-ones as TMC120 analogues

โœ Scribed by Yasser M. Loksha; Erik B. Pedersen; Paolo La Colla; Roberta Loddo

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
90 KB
Volume
44
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Abstract

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Different analogues of TMC120 derived from pyridazinโ€3(2__H__)โ€one rings were synthesized by coupling of 3,6โ€dichloropyridazine with arylacetonitriles, phenols and/or aniline derivative followed by hydrolysis and alkylation with different benzyl bromide derivatives.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis and complete assignment of the
Synthesis and complete assignment of the 1H and 13C NMR spectra of 6-substituted and 2,6-disubstituted pyridazin-3(2H)-ones
โœ Pedro Besada; Tamara Costas; Noemi Vila; Carla Chessa; Carmen Terรกn ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 116 KB

## Abstract Several pyridazinโ€3(2__H__)โ€one derivatives were synthesized starting from alkyl furans using oxidation with singlet oxygen to give 4โ€methoxy or 4โ€hydroxybutenolides, key intermediates of the synthetic strategy followed. For all pyridazinones reported, a complete assignment of the ^1^H