New routes to cis-1,2-hydroxyamines and related systems
β Scribed by Peter G Sammes; Dean Thetford
- Book ID
- 104218589
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 179 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## cis-Diaminotetralins 4 and 10 were converted in 4 steps to benzologs of the novel anticonvulsant U-54494. Attempted alkylation of 4 and 70 with 1,4-dibromobutane provided mixtures of the bis-pyrrolidino compounds and starting free bases together with the desired monopyrrolidino compounds 5 and
Binaphthyl derivatives 1-5, substituted in the 2-or 2,2Πpositions are used in palladium-catalyzed Suzuki coupling reactions. The mono-and bis-borylated coupling components 2, 4 and 5 can easily be prepared and purified, are air-stable and are therefore interesting starting materials for Suzuki coupl