New reagents for carboxyl-terminal peptide sequencing

✍ Scribed by G.Marc Loudon; M.E. Parham

• Book ID: 104242638
• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 276 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)91448-0

✦ Synopsis

The ready availability of solid supports of various types has opened the peptide field to a wide variety of reagents. Our program has been aimed at, among other things, the development of a carboxyl-terminal sequential pep-tide degradation. Ironically, the earliest efforts directed toward the development of a carboxyl-terminal degradation"-4 antedate the highly successful Edman amino-terminal procedure5 by several years. Despite the success of the Edman method, a method for the sequential degradation of peptides from the carboxyl terminus would complement the Edman procedure and would be highly useful in a number of situations6. Our initial efforts in the field have led to the devel