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New reactions in clavulanic acid biosynthesis

✍ Scribed by Craig A Townsend

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
160 KB
Volume
6
Category
Article
ISSN
1367-5931

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✦ Synopsis

Clavulanic acid is only a modestly effective antibiotic against bacterial infections in humans, but a potent inhibitor/inactivator of beta-lactamase enzymes that confer bacterial resistance. The biosynthetic pathway to clavulanic acid is considerably more complex than that to the structurally related penicillins and cephalosporins and has revealed several interesting reactions.

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Isolation of dihydroclavaminic acid, an
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