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Clavulanic acid, a β-lactamase inhibitor: biosynthesis and molecular genetics

✍ Scribed by P. Liras; A. Rodríguez-García


Publisher
Springer
Year
2000
Tongue
English
Weight
210 KB
Volume
54
Category
Article
ISSN
1432-0614

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Dioxo-6-(2-pyridyl)methylenepenicillanic acid (6) was prepared and found to be a potent p-lactamase inhibitor. Its reaction with sodium methoxide was studied to provide insight into its mechanism of enzyme inactivation.