New Pyrimidine Pathway involved in the Biosynthesis of the Pyrimidine of Thiamine
β Scribed by NEWELL, P. C.; TUCKER, R. G.
- Book ID
- 109658673
- Publisher
- Nature Publishing Group
- Year
- 1967
- Tongue
- English
- Weight
- 241 KB
- Volume
- 215
- Category
- Article
- ISSN
- 0028-0836
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A pyrimidine auxotroph of Escherichia coli was isolated which contained a defect in its ability to synthesize both oroate phosphoribosyl transferase, the product of the gene pyrE, and orotidine monophosphate decarboxylase, product of the gene pyrF. A single location on the E. coli linkage map was fo
Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. De novo pyrimidine biosynthesis is an example of one such metabolic pathway. In aninials a single protein called CADI-carries the first three steps