Regulation of the Pyrimidine Biosynthetic Pathway inPseudomonas mucidolens
β Scribed by Thomas P. West
- Book ID
- 106345133
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 197 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0003-6072
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π SIMILAR VOLUMES
## Abstract In research to date, regulation of the pyrimidine biosynthetic pathway at the level of gene expression has not been shown for wild type __Pseudomonas aeruginosa__. No repression was observed when uracil was added to the growth medium nor was any derepression seen when Pyr^β^ auxotrophs
In Saccharomyces cerevisiae, the protein encoded by the FUR1 gene is absolutely required for the expression of uracil phosphoribosyl transferase activity. The occurrence of semi-dominant mutations for 5-fluorouracil-(5FU)-resistance at this locus led us to clone and sequence the semi-dominant fur1-5