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New protopine alkaloids from Aristolochia constricta reduce morphine withdrawal in vitro

โœ Scribed by Anna Capasso; Nunziatina De Tommasi; Luca Rastrelli; Francesco De Simone


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
69 KB
Volume
14
Category
Article
ISSN
0951-418X

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Flavonol glycosides from Aristeguietia d
โœ Anna Capasso; Paola Saturnino; Francesco De Simone; Rita Aquino ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 49 KB ๐Ÿ‘ 1 views

The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong con