Flavonol glycosides from Aristeguietia discolor reduce morphine withdrawal in vitro

✍ Scribed by Anna Capasso; Paola Saturnino; Francesco De Simone; Rita Aquino

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 49 KB
• Volume: 14
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1

✦ Synopsis

The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (1 Â 10 À4 5 Â 10 À5 1 Â 10 À5 M), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion.

The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.