New prodrug approach for amino acids and amino-acid-like drugs
โ Scribed by T Aboul-Fadl; A El-Shorbagi
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 427 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0223-5234
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Each amino acid is represented by a vector of numerical measurements for the attributes of volume, area, hydrophilicity, polarity, hydrogen bonding, shape, and charge. Inter-residue distances are then calculated according to common metrics, and we introduce a new clustering objective function derive
Two new receptors, 9 and 13, have been prepared, utilising a pyridyl aryl ether unit in the rim of the macrobicyclic structure, and the crystal structures for both of these receptors are reported. The presence of the pyridyl unit provides additional hydrogen bonding functionality in comparison to ea