Amino acid esters of phenols as prodrugs
β
Ildiko M. Kovach; Ian H. Pitman; Takeru Higuchi
π
Article
π
1981
π
John Wiley and Sons
π
English
β 670 KB
pH-rate profiles were calculated for the hydrolysis of the glycine (II), P-aspartic acid (III), and a-aspartic acid (IV) esters of pacetamidopbenol (I) at 25" and = 1.0 M. The hydrolysis of esters I1 and 111 occurred predominantly uia intermolecular reactions involving water, hydroxide ion, and the