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Amino acid esters of phenolic drugs as potentially useful prodrugs

✍ Scribed by Ildako M. Kouach; Ian H. Pitman; Takeru Higuchi


Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
213 KB
Volume
64
Category
Article
ISSN
0022-3549

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Amino acid esters of phenols as prodrugs
✍ Ildiko M. Kovach; Ian H. Pitman; Takeru Higuchi πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 670 KB

pH-rate profiles were calculated for the hydrolysis of the glycine (II), P-aspartic acid (III), and a-aspartic acid (IV) esters of pacetamidopbenol (I) at 25" and = 1.0 M. The hydrolysis of esters I1 and 111 occurred predominantly uia intermolecular reactions involving water, hydroxide ion, and the