New Polyol Syntheses

✍ Scribed by Christoph Schneider

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 103 KB
• Volume: 37
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19980605)37:10<1375::aid-anie1375>3.0.co;2-h

✦ Synopsis

1,3,5,…︁-Polyol structures are characteristic components of polyene macrolide antibiotics such as filipin III (1). Iterative stereoselective alkylation of lithiated cyanohydrin acetonides and subsequent reductive decyanation is one possibility for the stepwise synthesis of this class of natural products characterized by a polyol framework of 1,3-diol units.