New P,N Ligands for Asymmetric Ir-Catalyzed Reactions

✍ Scribed by Tanasri Bunlaksananusorn; Kurt Polborn; Paul Knochel

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 133 KB
• Volume: 115
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200351936

✦ Synopsis

Scheme 1. The synthesis of 2-alkenylpyridines 13-15: a) [Pd(dba) 2 ] (2 mol %), dppf (2 mol %), alkenyl triflate 9 or 10, THF, LiCl, reflux, overnight; b) [Pd(PPh 3 ) 4 ] (5 mol %), PhB(OH) 2 , Na 2 CO 3 , toluene, MeOH, H 2 O, 85 8C, overnight. dba = dibenzylideneacetone, dppf = 1,1'-bis-(diphenylphosphanyl)ferrocene.

Scheme 2. Preparation of the P,N ligands 1-6.