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New phosphite method: the synthesis of oligodeoxyribonucleotides by use of deoxyribonucleoside 3'-[bis(1,1,1,3,3,3-hexafluoro-2-propyl) phosphites] as new key intermediates

✍ Scribed by Watanabe, Tetsuo; Sato, Hirotaka; Takaku, Hiroshi


Book ID
127205621
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
325 KB
Volume
111
Category
Article
ISSN
0002-7863

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## The deoxyribonucleoside 3'-bis(l ,I ,I ,3,3,3-hexafluoro-2-propyl) phosphite units (3) are used in the chemical synthesis of oligodeoxyribonucleotides on solid supports. The new phosphite units (3) were prepared easily by reaction of nucleosides and tris-( I ,I ,I ,3,3,3-hexafluoro-2-propyl) phos