New peptidomimetics in the chemistry of fibrinogen receptor antagonists

✍ Scribed by J. Gante; H. Juraszyk; P. Raddatz; H. Wurziger; S. Bernotat-Danielowski; G. Melzer; F. Rippmann

• Book ID: 104628400
• Publisher: Springer Netherlands
• Year: 1995
• Tongue: English
• Weight: 274 KB
• Volume: 2
• Category: Article
• ISSN: 1573-3149
• DOI: 10.1007/bf00119139

✦ Synopsis

RGD-peptidomimetics are currently being investigated as a class of potential antithrombotics that antagonize the fibrinogen receptor, GP IIb/IIIa, on the surface of platelets. These mimetics are expected to have decisive advantages -such as higher activity and specificity, oral bioavailability and longer duration of action -over known antithrombotics. For further optimization in this respect, novel peptidomimetic GP IIb/IIIa antagonists with an oxazolidinonemethyl central building block were synthesized. This building block proved to be very versatile as an 'anchor' for structurally different C-termini and was the starting point for highly efficient and orally active compounds.