New NO-Donors with Antithrombotic and Vasodilating Activities, Part 15 Nitrolic Acids

✍ Scribed by Klaus Rehse; Martin Herpel; Daniela Piechocki

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 392 KB
• Volume: 329
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19963290205

✦ Synopsis

Five 1 -0ximin0-1-nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1-Nitro-ethanone l-oxime (1, ethylnitrolic acid) 2 h after oral adminisbration to rats inhibited thrombus formation by a laser beam in msenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). "be blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pnssure effects can be dissociated. The in virro decomposition of 1 at 37 "C nearly exclusively gave Nfl and acetic acid indicating that HNO primarily had been formed.