New n-methyl-d-aspartate antagonists for the treatment of stroke
β Scribed by Elena Porsche-Wiebking
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 591 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0272-4391
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π SIMILAR VOLUMES
Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well-developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. S
## Abstract Syntheses of a series of enantiomerically pure, substituted analogues 7bβt of SDZ EAB 515 (7a) were described (__Schemes 1__ and __2__). Affinites for the NMDA receptor were measured ([^3^H]CGPβ39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional t