✦ LIBER ✦
N-methyl-D-aspartate antagonists: Ready for clinical trial in brain ischemia?
✍ Scribed by Gregory W. Albers; Mark P. Goldberg; Dr. Dennis W. Choi
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 638 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors may offer a new approach for the treatment of ischemic brain injury. This strategy is supported by a well-developed scientific foundation and encouraging results in a variety of in vivo and in vitro experimental models. Several specific antagonists, including MK-801, dextrorphan, dextromethorphan, and ketamine, have already been used at low doses in humans for other indications and are potential candidates for Phase I clinical trials.