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New molecular targets in bone metastases

✍ Scribed by D. Santini; S. Galluzzo; A. Zoccoli; F. Pantano; M.E. Fratto; B. Vincenzi; L. Lombardi; C. Gucciardino; N. Silvestris; E. Riva; S. Rizzo; A. Russo; E. Maiello; G. Colucci; G. Tonini

Book ID
117487887
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
189 KB
Volume
36
Category
Article
ISSN
0305-7372

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## BACKGROUND. Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced