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New Methods of Introducing the Carbo-t-butoxy Amino-Protecting Group. Preparation and Use of t-Butyl Cyanoformate and t-Butyl Iminodicarboxylate 1

โœ Scribed by Carpino, Louis A.


Book ID
124095772
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
743 KB
Volume
29
Category
Article
ISSN
0022-3263

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2-Phenyl isopropyl and t-butyl trichloro
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2-Phenylisopropyl and t-butyl trichloroacetamidates I and 2 are useful reagents for the esterification of N-protected aminoacids under mild neutral conditions. In the case of hydroxylcontaining amino acids, dialkylation occurs but no selectivity could be obtained