New Methods in Peptide Synthesis. II. Further Examples of the Use of the o-Nitrophenylsulfenyl Group for the Protection of Amino Groups 1,2
✍ Scribed by Zervas, Leonidas; Hamalidis, Charalambos
- Book ID
- 125447117
- Publisher
- American Chemical Society
- Year
- 1965
- Tongue
- English
- Weight
- 766 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0002-7863
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## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i
## Abstract 2‐Thiopyridone (2‐mercaptopyridine, **1**) was found to be a very suitable reagent for removing the __N__^α^‐o‐nitrophenylsulfenyl (NPS‐) group in both conventional and solid‐support peptide synthesis. A 3‐ to 5‐molar excess of the reagent together with an equivalent amount of glacial a
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t