New methods for ordering multivariate data: an application to the performance of investment funds

Effect of using an incorrect elimination

Effect of using an incorrect elimination rate constant in application of the Wagner–Nelson method to theophylline data in cases of zero order absorption

✍ John G. Wagner 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB

Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner-Nelson method to concentration-time data from another treatment (e.g. a sustained-release form). Since there is considerable intrasubject variation in the elimination rat