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New methodology for measuring anti-p53 antibodies in human serum

✍ Scribed by K. Angelopoulou; E.P. Diamandis

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
113 KB
Volume
26
Category
Article
ISSN
0009-9120

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✦ Synopsis

14.6%) colon; 0/11 (0%) Kaposi's sarcoma; 0/4 (0%) testicular; 2/148 (1.4%) hepatoma; 0/58 (0%) melanoma; 7/65 (10.8%) prostate; 3/46 (6.5%) pancreatic. Antibody titers varied dramatically from 2 to over 20. Overall positivity for the 1256 samples tested was 5.8%. Only one of 143 sera from normal blood donors (0.7%) gave a positive response, with a titer of 1.8. Our data are in fair agreement with published prevalence for antibody development in breast (7-9%) and lung (13%) cancer, and lymphoma (21%). We here report for the first time the highest prevalence of anti-p53 antibodies in ovarian and colon cancers. We are currently investigating whether the presence of such antibodies constitute a new diagnostic or prognostic test.

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