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New method of synthesis of substituted 2-pyridones

✍ Scribed by V. P. Litvinov; Yu. A. Sharanin; B. K. Promonenkov; L. A. Rodinovskaya; A. M. Shestopalov; V. Yu. Mortikov


Book ID
112448015
Publisher
Springer
Year
1984
Tongue
English
Weight
282 KB
Volume
33
Category
Article
ISSN
1573-9171

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A rapid and convenient synthesis of the 3-trifluoromethanesuifonyloxy-2-pyridone 2, one of the first examples of this class of compound, was achieved by Vilsmeier formylation and cyclisation of the acyl enamine 6. The triflate 2 was found to undergo a range of palladium-catalysed coupling reactions