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New kilogram-synthesis of the anti-alzheimer drug (−)-galanthamine

✍ Scribed by Laszlo Czollner; Werner Frantsits; Bernhard Küenburg; Ursula Hedenig; Johannes Fröhlich; Ulrich Jordis

Book ID
104259028
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
94 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A concise, scalable synthesis of (-)-galanthamine, a drug being used for the treatment of Alzhcimer's disease, is described. The yield of the critical phenolic coupling step was optimized to 45-50¢7,. For the reducti~m ~I the aryl bromide, air-activated LiAIH4 was used and racemic narwedine was converted to (-)-narwedinc by a soc~)nd order asymmetric transformation.

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