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New Insights into the Tumor Suppression Function of P27Kip1

✍ Scribed by Bruce E. Clurman and Peggy Porter

Book ID
123641625
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
528 KB
Volume
95
Category
Article
ISSN
0027-8424

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Cyclin-dependent kinases (CDKs), together with cyclins, their regulatory subunits, govern cell-cycle progression in eukaryotic cells. p27(Kip1) is a member of a family of CDK inhibitors (CDIs) that bind to cyclin/CDK complexes and arrest cell division. There is considerable evidence that p27(Kip1) p