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New implications for the QUAKING RNA binding protein in human disease

✍ Scribed by Carol Anne Chénard; Stéphane Richard

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
290 KB
Volume
86
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The use of spontaneously occurring mouse models has proved to be a valuable tool throughout the years to delineate the signals required for nervous system development. This is especially true in the field of myelin biology, with a large number of different models available. The quaking viable mouse models dysmyelination in the nervous system and links the QUAKING RNA binding proteins to myelination and cell fate decisions. In this Mini‐Review, we highlight the biological functions attributed to this KH‐type RNA binding protein and the recent achievements linking it to human disorders. © 2007 Wiley‐Liss, Inc.

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