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New imaging shows Alzheimer's unfolding in live brains

✍ Scribed by Coghlan, Andy

Book ID
123294690
Publisher
Reed Business
Year
2013
Tongue
English
Weight
661 KB
Volume
219
Category
Article
ISSN
0262-4079

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A new series of diphenylpropynone (DPP) derivatives for use in vivo to image Ξ²-amyloid (AΞ²) plaques in the brain of patients with Alzheimer's disease (AD) were synthesized and characterized. Binding experiments in vitro revealed high affinity for AΞ² (1-42) aggregates at a K(i) value ranging from 6 t