We have attempted to reactivate human herpesvirus 6 (HHV-6) by infection with HHV-7 using childhood exanthem subitum patients in vitro. Peripheral blood mononuclear cells (PBMCs) were collected from children who had a history of exanthem subitum(ES) by HHV-6 and were infected by human herpesvirus 7
New human herpesviruses; human herpesvirus 6 and 7
β Scribed by Koichi Yamanishi
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 134 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-9120
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β¦ Synopsis
acute phase and serological examination. Roseola is a common disease of infancy characterized by high fever for a few days and the appearance of a rash when the fever decreases. Symptoms are usually mild, but encephalitis and other complications of the central nervous system (CNS) have been reported. HHV-6 DNA can be detectable in cerebrospinal fluid of patients with neurological symptoms during roseola by polymerase chain reaction. Recently it is recognized that two distinct classes (variant A and B) of HI-IV-6 exist, and I-IHV-6B can be isolated from roseola patients. It is now believed that HHV-6 persists in the host after primary infection and that it can be reactivated later during immuuosuppression including AIDS and organ transplantation. Recently we found HI-IV-6 is reactivated during other virus infection including dengue virus and HHV-7.
π SIMILAR VOLUMES
## Abstract Infections with the Ξ²βherpesviruses human herpesvirusβ6 (HHVβ6) and human herpesvirusβ7 (HHVβ7) are ubiquitous in childhood. The immunosuppression secondary to organ or bone marrow transplantation together with posttransplantation management may favour viral replication and reactivation
Human herpesvirus 7, reported in 1990 is a lymphotropic member of the betaherpesvirus subfamily of herpesviruses. The virus is highly seroprevalent, primary infection usually occurs during childhood, and it has been associated with cases of exanthem subitum, pityriasis rosea, neurological manifestat
Human cytomegalovirus (HCMV), human herpesvirus-6 (HHV-6), and human herpesvirus-7 (HHV-7) DNA in peripheral blood leukocytes (PBL) of 61 bone marrow transplant recipients was monitored weekly during the first 12 weeks post-transplantation by a nested polymerase chain reaction (PCR). Thirty-seven (6