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New high-performance liquid chromatographic method for the determination of alprazolam and its metabolites in serum: instability of 4-hydroxyalprazolam

โœ Scribed by Virginia D. Schmith; Steven R. Cox; Michael A. Zemaitis; Patricia D. Kroboth


Publisher
Elsevier Science
Year
1991
Weight
311 KB
Volume
568
Category
Article
ISSN
0378-4347

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High performance liquid chromatographic
โœ Besenfelder, E. ;Endele, R. ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 215 KB ๐Ÿ‘ 2 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr