New heterocycles from 8-hydroxyquinoline via dipolar 1,3-cycloadditions: Synthesis & biological evaluation

✍ Scribed by Abdelmejid Bahloul; Abdelfatah Sebban; Zainaba Dardari; Mohammed Boudouma; Said Kitane; Touria Belghiti; Jean-Pierre Joly

• Book ID: 102339992
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2003
• Tongue: English
• Weight: 52 KB
• Volume: 40
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570400207

✦ Synopsis

Abstract

Diarylnitrilimine and arylnitriloxide dipoles react with two 8‐hydroxyquinoline substrates to give respectively pyrazolinic and isoxazolinic derivatives. The structure of these new heterocycles was established on the basis of their spectroscopic data and by chemical methods. The inhibition activity of one of these heterocycles was evaluated in vitro against 8 pathogenic μ‐organisms.