The majority of cancers present at a relatively advanced stage in which invasion within the primary organ is well established and metastases to lymph and distant organs are either clinically apparent or present at the microscopic level. However, it is increasingly recognized that the natural history
New Genetic Abnormalities and Treatment Response in Acute Lymphoblastic Leukemia
β Scribed by Jules P.P. Meijerink; Monique L. den Boer; Rob Pieters
- Book ID
- 117822113
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 251 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1532-8686
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## Abstract Fluorescence in situ hybridization (FISH) studies were performed in three cases of acute lymphoblastic leukemia (ALL) with marker chromosomes to analyze the contribution of chromosome 21 in these markers. FISH with a chromosome 21 painting probe confirmed that chromosome 21 was involved
Loss of chromosome 20 and rearrangement of the short arm of chromosome 9 were identified by banding analysis of three adult patients with acute lymphoblastic leukemia (ALL). The G-banding pattern suggested an identical deletion of 9p, but, also, an unbalanced translocation with chromosome 20 was tak