Treatment of acute lymphoblastic leukemia in adults
β Scribed by Prof. Tiziano Barbui; Renato Bassan; Teodoro Chisesi; Raffaele Battista; Sergio Cortelazzo; Francesco Rodeghiero; Giovanni Capnist; Anna D'emilio; Piera Viero; Enrico Dini
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 276 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0278-0232
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β¦ Synopsis
Thirty-seven adult patients with acute lymphoblastic leukemia were treated with a protocol called HEAV'D including Adriamycin, Vincristine, L-Asparaginase, Cyclophosphamide and Dexamethasone. The complete remission rate was 70 per cent. The median duration of remission was more than 30 months. Patients with initial leukocyte count below 20 000/mmc experienced a longer remission (median not reached) than patients with a leukocyte count above 20 000/mmc (median 10 months).
π SIMILAR VOLUMES
Ultrastructural cytochemical studies revealed peroxidase activity in five of 25 adult patients with apparent null lymphoblastic leukemia (ALL) in whom the peroxidase reaction studied with light microcopy was negative. None of these 5 patients responded to a chemotherapy regimen used for adult ALL. T
## Background: Anti-b4-blocked ricin is an immunotoxin comprised of an anti-cd19 murine monoclonal antibody (b4) conjugated to blocked ricin, which has cytotoxic activity in patients with lymphoid malignancies. ## Methods: Adults with untreated acute lymphoblastic leukemia (all) were treated with