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New GABA-Modulating 1,2,4-Oxadiazole Derivatives and Their Anticonvulsant Activity.

✍ Scribed by Hans-Joachim Lankau; Klaus Unverferth; Christian Grunwald; Helge Hartenhauer; Kristina Heinecke; Katrin Bernoester; Rita Dost; Ute Egerland; Chris Rundfeldt


Publisher
John Wiley and Sons
Year
2007
Weight
18 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract A series of new 2,5‐disubstituted‐1,3,4‐oxadiazole and 1,2,4‐triazole derivatives were synthesized by heterocyclization of acid hydrazide **1** and thiosemicarbazide derivative **2**. Furthermore, the acyclic __C__‐nucleoside analogs were prepared by cyclization of their corresponding s