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Synthesis and Antimicrobial Activity of New 2,5-Disubstituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles and Their Sugar Derivatives

✍ Scribed by Wael A. El-Sayed; Omar M. Ali; Hend A. Hendy; Adel A.-H. Abdel-Rahman

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 354 KB
Volume: 30
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.201100029

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✦ Synopsis

Abstract

A series of new 2,5‐disubstituted‐1,3,4‐oxadiazole and 1,2,4‐triazole derivatives were synthesized by heterocyclization of acid hydrazide 1 and thiosemicarbazide derivative 2. Furthermore, the acyclic C‐nucleoside analogs were prepared by cyclization of their corresponding sugar hydrazones by reaction with acetic anhydride. The antimicrobial activity of the prepared compounds was evaluated and some of the synthesized compounds revealed good activities against fungi.

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