New functional sites in MutS affect DNA mismatch repair
β Scribed by TianYing Zhong; LiJun Bi; XianEn Zhang
- Book ID
- 107349847
- Publisher
- Science in China Press (SCP)
- Year
- 2010
- Tongue
- English
- Weight
- 444 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1674-7305
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Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes. Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers. A defect in DNA mismatch repair results in an RER (replication e
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